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Carlos Augusto Alves Santana (born 20 July, 1947) is a Mexican-born American Grammy Award-winning rock musician and guitarist. Santana became famous in the late 1960s and early 1970s with his band, Santana, which pioneered a blend of rock, salsa and jazz fusion. The band's sound featured his melodic, blues-based guitar lines set against Latin percussion such as timbales and congas. Santana continued to work in these forms over the following decades. He experienced a sudden resurgence of popularity and critical acclaim in the late 1990s. Rolling Stone also named Santana number 15 on their list of the 100 Greatest Guitarists of All Time in 2003.

Santana's record sales in the 1990s were very low. Toward the end of the decade he was without a contract. However, Arista Records' Clive Davis, who had worked with Santana at Columbia Records, signed him and encouraged him to record a star-studded album with mostly younger artists. The result was 1999's Supernatural, which included collaborations with Everlast, Rob Thomas of Matchbox Twenty, Eric Clapton, Lauryn Hill, Wyclef Jean, Cee-Lo, Maná, Dave Matthews, K. C. Porter, J. B. Eckl, and others.

He also created a line of shoes at some time.

However, the lead single was what grabbed the attention of both fans and the music industry. "Smooth", a dynamic cha-cha stop-start number co-written and sung by Rob Thomas of Matchbox Twenty, was laced throughout with Santana's guitar fills and runs. The track's energy was immediately apparent on radio, and it was played on a wide variety of station formats. "Smooth" spent twelve weeks at number one on the Billboard Hot 100, becoming in the process the last #1 single of the 1990s. The music video, set on a hot barrio street, was also very popular. Supernatural reached number one on the US album charts and the follow-up single, "Maria Maria", featuring the R&B duo The Product G&B, also hit number one, spending ten weeks there in the spring of 2000. Supernatural eventually sold over 15 million copies in the United States, making it Santana's biggest sales success by far.

Supernatural won nine Grammy Awards (eight for Santana personally), including Album of the Year, Record of the Year for "Smooth", and Song of the Year for Thomas and Itaal Shur. Santana's acceptance speeches described his feelings about music's place in one's spiritual existence. In 2001, Santana's guitar skills were featured in Michael Jackson's song "Whatever Happens", from the album Invincible.

In 2002, Santana released Shaman, revisiting the Supernatural format of guest artists including P.O.D. and Seal. Although the album was not the runaway success its predecessor had been, it produced two radio-friendly hits. "The Game of Love" featuring Michelle Branch, rose to number five on the Billboard Hot 100 and spent many weeks at the top of the Billboard Adult Contemporary chart, and "Why Don't You & I" written by and featuring Chad Kroeger from the group Nickelback (the original and a remix with Alex Band from the group The Calling were combined towards chart performance) which reached number eight on the Billboard Hot 100. "The Game of Love" went on to win the Grammy Award for Best Pop Collaboration with Vocals.

In August 2003, Santana was named fifteenth on Rolling Stone magazine's "List of the "100 Greatest Guitarists of All Time".

In 2005, Herbie Hancock approached Santana to collaborate on an album again using the Supernatural formula. Possibilities was released on August 30, 2005, featuring Carlos Santana and Angélique Kidjo on "Safiatou". Also, in 2005, the fellow Latin star Shakira invited Santana to play soft rock guitar ballad Illegal on her second English-language studio album Oral Fixation Vol. 2.

Santana's 2005 album All That I Am consisting primarily of collaborations with other artists; the first single, the peppy "I'm Feeling You", was again with Michelle Branch and The Wreckers. Other musicians joining the mix this time included Steven Tyler of Aerosmith, Kirk Hammett from Metallica, hip-hop/reggae star Sean Paul and R&B singer Joss Stone. In April and May 2006, Santana toured Europe, where he promoted his son Salvador Santana's band as his opening act.

In 2007, Santana appeared, along with Sheila E. and José Feliciano, on Gloria Estefan's album 90 Millas, on the single "No Llores". He also teamed again with Chad Kroeger for the hit single "Into the Night."

On October 19, his wife of 34 years, Deborah, filed for divorce citing "irreconcilable differences".

In 2008, Santana started working with his long-time friend, Marcelo Vieira, on his solo album Marcelo Vieira's Acoustic Sounds, which is due to be released at the end of the year. It features tracks such as "For Flavia" and "Across the Grave", the later featuring heavy melodic riffs by Santana.

Carlos Santana performed at the 2009 American Idol Finale with the top 13 finalists, which starred many acts such as KISS, Queen and Rod Stewart. On July 8 2009, Carlos Santana appeared at the Athens Olympic Stadium in Athens with his 10-member all-star band as part of his "Supernatural Santana - A Trip through the Hits" European tour. On July 10 2009, he also appeared at Philip II Stadium in Skopje. With 2.5 hours concert and 20 000 people, Santana appeared for the first time in that region.

Santana is being featured as a playable character in the music video game Guitar Hero 5. A live recording of his song No One To Depend On will also be included in game, which will be released on September 1.

Carlos has recently opened a chain of upscale Mexican restaurants called "Maria Maria". It is a combined effort with renown Chef Roberto Santibanez. They are located in Tempe AZ, Mill Valley & Walnut Creek CA, and Austin TX, and soon to Boca Raton FL.